A good cancer medicine will stop cells from dividing out of control. What might be the side effects of this medicine? Explain your answer.

Answers

Answer 1
Cancer cell proliferation relies on the ability of cancer cells to grow, transition through the cell cycle, and divide. To identify novel chemical probes for dissecting the mechanisms governing cell cycle progression and cell division, and for developing new anti-cancer therapeutics, we developed and performed a novel cancer cell-based high-throughput chemical screen for cell cycle modulators. This approach identified novel G1, S, G2, and M-phase specific inhibitors with drug-like properties and diverse chemotypes likely targeting a broad array of processes. We further characterized the M-phase inhibitors and highlight the most potent M-phase inhibitor MI-181, which targets tubulin, inhibits tubulin polymerization, activates the spindle assembly checkpoint, arrests cells in mitosis, and triggers a fast apoptotic cell death. Importantly, MI-181 has broad anti-cancer activity, especially against BRAFV600E melanomas.

Related Questions

Worth 50 points

What gives a protein its unique shape?

Question 5 options:

neither


the unique sequence of amino acids in its polypeptide chain


the unique folding of the polypeptide chain

Answers

Answer:

the unique sequence of amino acids in its polypeptide chain

Explanation:

Protein is a large molecule which is made from a chain of smaller molecules called amino acids. There are twenty amino acids exist, and when they bond together they make unique proteins depending on their sequence in the chain.

count how many cells are are in this picture

Answers

Answer:

there is no picture there lol

Wastewater treatment plants can make wastewater drinkable again. Which of
the following is a technology used to remove solids from the water?
O A. Treating the water with certain bacteria and air
O B. Shaking and skimming them from the surface of the water
O c. Adding hydrochloric acid and chlorine to the water
O D. Filtering and allowing them to settle out of the water
SUBMIT

Answers

Answer:

D

Explanation:

I'm not 100% sure this is right but it's a better answer than B

A concentration gradient affects the direction that solutes diffusion. Describe how molecules move with respect to the concentration.

Answers

Answer:a

Explanation: took it

Answer:

If a concentration gradient exists, molecules will move from areas of high concentration to areas of low concentration until the concentration gradients have equalized

Explanation:

I don't really have an explanation but there's the CORRECT answer.

HELPP!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
In the cells of humans and other animals, a great deal of energy is dedicated to operating a pump that transports sodium (Na+) ions out of cells and potassium (K+) ions into cells. This transport creates a chemical and electrical gradient. Maintaining the proper balance of sodium and potassium is critical to ensuring that nerve cells work properly. Nerve cells drive muscle contractions—including heart muscles—and are responsible for animals’ abilities to sense their environment and for humans’ ability to think.

Scientists gain a better understanding of the sodium-potassium pump by creating models of what the pump accomplishes. Such models are used to examine many other complex processes as well.

This model of the sodium-potassium pump illustrates the process by which sodium is pumped out of cells and potassium is pumped in. The sodium-potassium pump moves the two different ions in opposite directions.



Where in a cell does this transport process take place?

A.
nucleus
B.
cell wall
C.
cell membrane
D.
vesicle

Answers

The Transport process takes place in cell membrane.

What is Transport?

Cell transport describes the transportation of a material across a cell membrane. The chemical has the ability to enter or exit cells.

The plasma membrane and cell membrane are both permeable to different substances. The nature of the plasma membrane is quite selective.

Cell transport is very important for transport of molecules. There are two transport of cell transport of endocytosis and exocytosis.

Therefore, The Transport process takes place in cell membrane.

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5. Predicting: Suppose you went on a run on a hot day in August. You did not drink a lot of water
beforehand. How would this affect your urine formation

Answers

you would have a full bladder

Which of the following is an indicator of good water quality? (2 points)

Answers

Answer→ Physico-chemical indicators

Explanation ≈  They include dissolved oxygen, pH, temperature, salinity and nutrients (nitrogen and phosphorus). They also include measures of toxicants such as insecticides, herbicides and metals.

which selective is a characteristic of both living and non living thing? metabolism, cells, energy, or subatomic particles?

Answers

Answer:

The same atoms and subatomic particles can be found in both.

Differentiate betweeli population density and
population distribution.

Answers

Answer:

The main difference between population density and population distribution is that the population density is the number of individuals per unit land whereas the population distribution is the spreading of people over an area of land. Furthermore, population density is unable to describe where the population actually lives, unlike population distribution.

Population density and population distribution are two measurements of population used in a variety of applications in ecology.

Explanation:

please help i don’t know how to do this :(

Answers

Answer:

polysacchiride is B.

Nucleic acid is C

Protein is D

Lipid is A

Explanation:

Crowdsourcing was used to solve problems for what science discipline?

Answers

Answer:

A. Science relies on observation, measurement, and experimentation.

Explanation:

ok Np bye!

Which pH indicates a basic solution?
1.
1
2.
5
3.
7
4.
12

Answers

Answer:

7

A pH value greater than 7 indicates a basic solution. The more the pH value exceeds 7, the more basic is the solution.

7 is the answer.

If the pH is 1, that means the substance is sour or acidic.

If it has a pH of 5, then it is not that acidic.

If something has a pH of 12, then it is almost completely basic.

If something has a pH of 7, then it is basic.

Hope it helps! :)

Have you ever wondered how we can grow from one cell to millions? How do you think this happens?

Answers

Answer:

If you think about it, the fact that a single cell can grow into an adult with trillions of cells is pretty awesome. ... It's a process called the cell cycle. Entire organisms grow, and develop by going through the cell cycle again and again. The cell cycle also helps us maintain a healthy body.

From a single cell to multiple cellular organism is formed by different complex mechanism like by cell division which involves a central dogma of life includes three process such as replication, transcription and translation and fourth one is reverse transcription.

what is central dogma ?

The ‘Central Dogma’ is the flow of transfer of genetic information, from DNA to RNA to make a functional product, a protein, was first proposed in 1958 by Francis Crick.

DNA contains the genetic information needed to make proteins, and RNA act as a messenger that carries this information to the ribosomes where the information is translated into protein.

The process by which the DNA information converted into protein called gene expression which can occur in two stages like transcription and translation.

The central dogma occurs most frequently in our cells  in three stages such as DNA replication that refers to make new DNA from pre existing DNA, transcription to make RNA from DNA and translation from RNA to protein.

Reverse transcription is defined as the transfer of information from RNA to make new DNA in a reverse manner which occur mainly in retroviruses, such as HIV.

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Match the key elements in the Scientific Method with the correct description. 4. A researcher asks a focused research question or states their reason for the study
A) state the problem
B) state the hypothesis
C) come to a conclusion
D) collect background information
E) conduct experiments

Answers

b. State the hypothesis

How does water pass through the cell membrane using passive transport

Answers

Answer:

Hope it helped you brainiest plz and thank you have a great day!!!

Explanation:

How does water pass through the cell membrane using passive transport?

It pass through the passive transport by the simple diffusion of water which can make it simple for a cell membrane to go through.

Write down the tRNA anti-codons that pair with the mRNA strand.
Note: Please use capital letters, and follow this format: A-A-A-A-A-A-A-A

Answers

Answer:

tRNA molecules bring a specific amino acid to the ribosome, according to the mRNA codon.

Explanation:

In the context of protein synthesis, an mRNA molecule contains the specific codons that encode the amino acids that will be part of the protein. The tRNA is in charge of bringing the amino acids to the ribosome, according to the specific information of the mRNA codons.

-- How do scientists predict the weather over our future?

Answers

The Short Answer:

To predict future climate, scientists use computer programs called climate models to understand how our planet is changing. Climate models work like a laboratory in a computer. ... Scientists use computer programs called climate models to understand how our planet is changing.

What subatomic particles are found on the inside of an atom (the nucleus) and what subatomic particles are found on the outside (in the rings)?

Answers

Answer:

In the nucleus of an atom, we find 2 subatomic particles, protons, and neutrons.

On the outside, on the rings, are electrons.

I hope this helps you somewhat! :D  

TheQuestionIsWhy

Question 4 of 34 4
Where are electrons located?

Answers

Answer: they rotate the nucleus creating the "outer casing" that you see in diagrams

Explanation:

Which of the following best describes the composition of a nucleotide?

Select one:

a.
a pair of six-carbon rings attached to each other

b.
a carbon atom joined to a hydrogen and three functional groups

c.
a chain of carbon atoms with a carboxyl group bonded to one end

d.
a five-carbon sugar attached to a phosphate group and a nitrogenous base

Answers

Answer:

d

Explanation:

Nucleotide is composed of 3 main subunits, which are nucleobase, a five-carbon sugar (ribose or deoxyribose), and a phosphate group consisting of one to three phosphates.

D

A nucleotide is composed of sugar, 5 rings, with a phosphate and a nucleotide.

Which of these questions could BEST be answered with the methods of science?

a. How is Earth different from other planets?
b. What does it mean to be a good person?

c. Will computers make us more or less human?

Answers

Answer:

A

Explanation:

It is about planets and planets are in space.

Radiating heat travels in waves moving at about 300,000 km/sec true or false?

Answers

Answer:

True

Explanation:

arfswg;iljghobfweolbvflds

Answer:

Yes

Explanation:

because of the Hottness

What do frogs (and all animals) need in order for their bodies to grow, develop, and repair themselves? How do animals use these materials for bodily processes?

Answers

Answer:

:P :P :P :P :P :P :P :P :P :P :P :P

feel the inside of your elbow as you lift a book. you should feel a strong cord. what is this? what does it do?​

Answers

The strong cord you feel in your elbow is called your Oblique cord.

We feel the inside of the elbow as we lift a book. We should feel a strong cord. This cord is known as Oblique cord.

What is the Oblique cord?

The oblique cord is a ligament which is present between the ulnar and radius bones in the forearm region near the elbow. Oblique cord takes the form of a small, flattened band, which is extending downward and lateralward, from the lateral side of the ulnar bone tuberosity at the base of the coronoid process to the radius of a little below the radial tuberosity. The fibers in this cord runs in the opposite direction to those of the Interosseous membrane of the forearm region of the hand.

The oblique cord may simply be defined as an additional tie which is between the radius and ulna of the hand which is aiding other soft tissue structures such as the annular ligament and interosseous membrane. Additionally, the oblique cord may also prevent the anterior shearing of the proximal radius under the extreme compressive loads.


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ASAP PLEASE


What are some careers/jobs that use the scientific method while working?
Explain how each step is connected to a specific part in the job also


At least 3 THANK YOU

Answers

Answer:

Maybe an engineer.

Explanation:

They build stuff do experiments and have to guess and make hypothesis (what science has)❤️ I. really hope this helps:)

A clean suit should be worn at the crime scene on Willow Lane by CSI personnel to _____.


identify the CSI personnel from other first responders
identify the CSI personnel from other first responders

protect against an unwanted transfer of evidence
protect against an unwanted transfer of evidence

keep their clothes from being spoiled by bodily fluids
keep their clothes from being spoiled by bodily fluids

maintain personal safety around unhealthy contaminates

Answers

Answer:

identify the CSI personnel from other first responders

Explanation:

Sort the phrases based on whether they represent kinetic energy or potential energy.

Answers

Answer: The main difference between potential and kinetic energy is that one is the energy of what can be and one is the energy of what is. In other words, potential energy is stationary, with stored energy to be released; kinetic energy is energy in motion, actively using energy for movement

Explanation:

hope helps

What gases was not present in earths earth atmosphere

Answers

Answer:

Primitive Earth (Before life) contained no or very little Oxygen (element#8)

According to scientific theory:

Earth had no oxygen to begin with. It had a lot of carbon dioxide, though. Somehow (We still do not know how they started growing) single-celled Carbon Dioxide-breathing bacteria slowly, over thousands to millions of years, turned most carbon dioxide into oxygen, supporting new types of life.

:)


What is meant by a phenotype ratio in a Punnett square? (1 point)

A. the fraction of possible offspring that can be observed to have a trait

B. the number of genes that are possible in offspring

C. the number of alleles in possible offspring

D. the fraction of possible offspring that contain a certain allele in their genes

Answers

Given the nature of a punnet square, we can conclude that the ratio in question refers to the combination of genotypes present in the square.

A punnet square is a diagram used to attempt to predict the genetic composition for the offspring of certain parents, that is the genotype for this specific cross. This is done by creating a square in the form of a grid and placing the genotypes of the parents on the outside of this then crossing them along the inside.

This diagram provides us with the probability of each genotype outcome. This is known as the phenotype ratio. The phenotypic ratio is the amount of times a specific outcome, such as a certain pair of alleles appears in the predicted genotypes of any of the offspring pertaining to this cross.

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Answer:

ratio based on the phenotypes of offspring and determined using tools such as Punnett Squares.

in this environment, the fish represents which type of organism?
A. Heterotroph
B. Producer
C. Autotroph

Answers

Heterotroph, a fish cannot make its own food/energy so that rules out producer and autotroph
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