PLEASE HELP!!
What can happen to an enzyme that will cause it to no longer function properly?

Answers

Answer 1

Answer:

Extreme temperatures can cause an enzyme to lose its shape (denature) and stop working.

Explanation:

hope this helps!


Related Questions

Anyone in grade 10-11?? Who has ig or S?

A hot air balloon lifts 50 meters vertically into the air and then comes back down. What are the displacement and distance of the balloon’s flight?

Answers

The displacement is zero and the distance is 100 meters

Define aerobic respiration in detail.

Answers

Answer:

Aerobic respiration is the process in which oxygen is used to create energy from carbohydrates. This process is enzyme-controlled, and the energy stored is released during photosynthesis. This process has 4 stages; glycolysis, link reaction, the Krebs cycle, and last but not least, oxidative phosphorylation.

2013 martins a prospective study comparing single and double fascicular transfer to restore elbow flexion after brachial plexus injury.pdf

Answers

Study comparing single and double fascicular transfer to Elbow flexion strength was evaluated with a push-and-pull dynamometer 12 months after surgery.

When the upper brachial plexus is injured, the biceps muscle can be reinnervated to restore elbow flexion (single reinnervation), but simultaneous brachialis and biceps function restoration (double reinnervation) has been advised to increase elbow flexion strength. The goal is to assess the morbidity and results of single versus double muscle reinnervation in regaining elbow flexion after incomplete brachial plexus injury. Methods: Single or double muscle reinnervation was prospectively performed on 40 consecutive patients. Twelve months following surgery, the elbow flexion strength was assessed using a push-and-pull dynamometer. Both groups' elbow flexion strength test results were comparable.

To learn more about injured.

brainly.com/question/24881733

#SPJ4

Repetitive dna sequences usually evolve very quickly. based on this fact, molecules that have a rapid mutation rate are best used when studying relationships among?

Answers

Repetitive DNA sequences usually evolve very quickly. Based on this fact, molecules that have a rapid mutation rate are best used when studying relationships among: very closely related species.

Repetitive DNA sequences are the part of DNA segment that are repeated multiple time. These sequences are also known by the name tandem repeats. The repeats are usually a part of the non-coding part of the DNA strand.

Mutation is the alteration in the sequences of DNA. This may or may not result in the change of some trait or characteristic. The mutation is caused due to deletion, addition, inversion or repetition of some sequences in the gene. Some mutations do not show any effect and hence are called silent mutations.

To know more about mutations, here

brainly.com/question/17130462

#SPJ4

fecal microbiota transplantation is superior to fidaxomicin for treatment of recurrent clostridium difficile infection

Answers

The recommended course of treatment for recurrent Clostridium difficile infection (rCDI) is fecal microbiota transplantation (FMT).

A significant contributor to nosocomial diarrhea, Clostridium difficile infection (CDI) accounts for 20%-30% of diarrhea brought on by antibiotics. The prevalence of CDI is rising both in hospital settings and the general population, and the condition represents a significant threat to public health. Advanced age, comorbidity, and recent antibiotic usage are risk factors for developing CDI. Ninety-day mortality is up to 22%, and CDI is a contributory factor in up to 40% of these fatalities. The chance of a recurrence is 20% and rises with age over 65, a serious underlying condition, and the use of antibiotics or proton pump inhibitors.

Learn more about the Microbiota with the help of the given link:

https://brainly.com/question/15556871

#SPJ4

you are estimating the time since the divergence of two species and used hemoglobin for your molecular clock. you would like to get independent support for your estimate. if you also use cytochrome c, which result do you expect?

Answers

The result that one should be expected from this experiment is the number of amino acid differences between the two species will be fewer for cytochrome C than for hemoglobin.

What is a factor that is used as a molecular clock?

A molecular clock utilizes DNA sequences in order to calculate how long it has been since related species are typically separated or diverged from their common ancestors.

According to the question, the accumulation of amino acids in two species will be less in number as compared to the existence of hemoglobin genes. This is because this type of estimation independently supports the evidence.

Therefore, the number of amino acid differences between the two species will be fewer for cytochrome C than for hemoglobin is the result that one should be expected from this experiment.

To learn more about Molecular clock, refer to the link:

https://brainly.com/question/5172365

#SPJ4

Your question seems incomplete. The most probable complete question is as follows:

The number of amino acid differences between the two species will be the same for both genes.The number of amino acid differences between the two species will be fewer for hemoglobin than for cytochrome c.The number of amino acid differences between the two species will be fewer for cytochrome c than for hemoglobin.

What type of approach did helmholtz take in investigating how the nervous system works?

Answers

Helmholtz took the Empiricist approach in investigating how the nervous system works.

In the late 1800s, a German scientist named Hermann von Helmholtz took the empiricist approach in investigating how the nervous system works. He did this by creating detailed models and theories based on observations and experiments.

Helmholtz's work was extremely influential in the development of modern neuroscience. His theories helped to explain how information is transmitted between neurons, how sensory information is processed, and how motor commands are generated.

Despite the advances that have been made since Helmholtz's time, his approach remains an important part of neuroscience today. By constantly observing and experimenting, we can continue to learn more about how the nervous system works and how to optimize its function.

Learn more on Empiricist approach here:

https://brainly.com/question/24678786

#SPJ4

quantification of gait parameters in freely walking wild type and sensory deprived drosophila melanogaster

Answers

Quantification of gait parameters in freely walking wild type and sensory deprived drosophila melanogaster. True.

The analysis of locomotion in massive animals, drastically mammals, often is based on the position of visual marks generally joints that may be without problems detected and tracked.

However, in smaller insects including Drosophila, any such method becomes no longer most effective technically tough however is likewise probable to disturb on foot. Such challenges have a more distinct examination of the that incorporate  walks conduct to overcome those boundaries and  the biomechanical features on foot in Drosophila we became to an optical effect referred to as general internal mirrored image.

However, if a denser material, which includes the tarsus of an insect leg, contacts the surface of the glass, then the domestically  overall internal mirrored image will scatter the light.

Disclaimer:- your question is incomplete, please see below for the complete question.

Quantification of gait parameters in freely walking wild type and sensory deprived drosophila melanogaster. T/F

Learn more about Drosophila here:- https://brainly.com/question/27652505

#SPJ4

During prebiotic evolution, macromolecules eventually began to replicate based on?

Answers

During prebiotic evolution, macromolecules eventually began to replicate based on smaller complimentary units.

The transition from non-living to living materials is a gradual one in the origin of life. Simple inorganic compounds could have formed simple organic compounds (monomers) such as amino acids and nucleotides, through an energy-driven reaction. These monomers were combined to create larger, more complicated compounds, such as polymers of proteins and nucleic acids. The polymers might have come together into self-sustaining or self-replicating units or structures.

These self-sustaining or self-replicating units or structures (macromolecules) may group together to form colonies that perform metabolism, or they may be encased in membranes to form cell-like structures.

Hence, we can say that smaller complimentary units are the basis of macromolecule replication.

Learn more about evolution, here :

https://brainly.com/question/20938537

#SPJ4

As noted in Figure 53.2, an important assumption of the mark-recapture method is that marked individuals have the same probability of being captured as unmarked individuals. Describe a situation where this assumption might not be valid, and explain how the estimate of population size would be affected.

Answers

If an animal is lured in with food, it is more likely to be recaptured if it craves the same food. Because the population size (N) = mn/x N, the number of marked animals recaptured (x) would be an overestimation.

Briefing :

Alternatively, if an animal has a bad experience during capture and learns from it, it may be less likely to be captured again. In this example, X is an underestimation and N is an overestimation.

Population size :

Population size is defined in population genetics and population ecology as the number of individual organisms in a population. Population size is intimately related to genetic drift and is the fundamental cause of phenomena such as population bottlenecks and the founder effect. The four primary factors are the birth rate, the death rate, immigration, and emigration.

To know more about birth rate visit :

https://brainly.com/question/2278740

#SPJ4

Which example is a scientific question that could be used to start a scientific..
investigation?
A. What is the best method for open-ocean fishing?
B. Are trawling nets easier to use than other fishing nets?
C. Is the use of trawling nets an ethical fishing method?
OD. Which type of fish is most commonly caught in trawling nets?
SUBMIT
k

Answers

Answer:

D. Which type of fish is most commonly caught in trawling nets?

Explanation:

A. fishing question not science

B. nets question not science

C. ethics question not science

How many different kinds of gametes (with respect to a particular gene locus) are formed by an individual who is homozygous at that locus?

Answers

There is only one kind of gamete formed by an individual who is homozygous at that particular locus.

What is the law of segregation?

Gregor Mendel investigated the trait inheritance in pea plants. He put up a theory in which attributes were determined by pairs of "heritable elements," or genes. Alleles, which are various variants of a gene, exist.

The appearance of the organism is determined by a dominant allele, which conceals a recessive gene. Each gamete produced by an organism has a single gene copy that is chosen at random.

The genotypes (allele combinations) and phenotypes (observable qualities) of progeny from genetic crossings may be predicted using a Punnett square. An organism with a dominant trait can be tested to see if it is homozygous or heterozygous using a test cross.

Therefore, only one kind of gamete will be formed by an organism that is homozygous at that particular locus.

Read more about the law of segregation, here

https://brainly.com/question/13434823

#SPJ4

During which prenatal period do the nervous system, organs, and muscles become organized and connected, and behaviors suck as kicking and thumb sucking appear?

Answers

During the prenatal period, the fetus's nervous system, organs, and muscles become organized and connected. This is when behaviors such as kicking and thumb sucking appear.

This is an amazing time for the fetus, as they are growing and developing at a rapid pace. It is also a time when they are extremely vulnerable to anything that could potentially harm them.

That is why it is so important for pregnant women to take care of themselves during this time. Eating a healthy diet, getting enough rest, and avoiding stress are all crucial for a healthy pregnancy.

If you are pregnant, or know someone who is, make sure to take care of them during this precious time.

Learn more on fetus here:

https://brainly.com/question/1311741

#SPJ4

for ingested foods, the first opportunity for enzymatic digestion occurs in the . view available hint(s)for part a for ingested foods, the first opportunity for enzymatic digestion occurs in the . pancreas stomach large intestine small intestine mouth

Answers

According to the research, the correct option is mouth. For ingested foods, the first opportunity for enzymatic digestion occurs in the mouth.

What is enzymatic digestion?

They are proteins whose function is that they allow the digestion of food and the assimilation of nutrients and the decomposition of the different nutrients are secreted by the pancreas and go to the duodenum to exert their action, such as amylase, lipase.

In this sense, enzymes, since they are proteins that break down nutrients, are formed inside the cells present in the mouth and have a prominent role in all phases of digestion, which starts from the mouth with the saliva that contains enzymes for digestion, preventing the formation of toxins and other substances harmful to the digestive tract.

Therefore, we can conclude that according to the research, the correct option is mouth. For ingested foods, the first opportunity for enzymatic digestion occurs in the mouth.

Learn more about enzymatic digestion here: https://brainly.com/question/9083240

#SPJ1

scientists calculated the net primary productivity at two different forest sites. both forests have the same gross primary productivity. forest a has a net primary productivity of 1,650kcal/m2/year, and forest b has a net primary productivity of 1,110kcal/m2/year.

Answers

A producers have lower rates of cellular respiration than forest B producers.

What is NPP and GPP in ecosystem?

Gross primary productivity is the rate of photosynthesis. Net primary productivity is the rate of storage of organic matter except which is utilized for the respirations by plants. Hence , we can say that NPP = GPP- plant respiration .  

Forest A producers have lower rates of cellular respiration than forest B producers. (Since gross primary productivity is the same, forest B has a lower net primary productivity; therefore, it has a higher rate of cellular respiration.)

To learn more about NPP refer

https://brainly.com/question/14143277

#SPJ4

A stretch of river running through a state wildlife preserve is 25,000 m long. A team of conservationists make a scale model of the river that is 1 m long. What is the scale of the model?​

Answers

Since the state wildlife preserve is 25,000 m long and a team of conservationists made a scale model of the river that is 1 m long, the scale of this model is: B. 1:25,000.

What is scale factor?

A scale factor can be defined as the ratio of two (2) corresponding length of sides or diameter in two similar geometric figures such as equilateral triangles, river, planets in our solar system, etc.

Let S represent the length of the state wildlife.Let R represent the length of the river.

For this model, the scale factor would be given by:

Scale factor = R:S

Scale factor = 1:25,000.

Read more on scale factor here: brainly.com/question/2826496

#SPJ1

Complete Question:

A stretch of river running through a state wildlife preserve is 25,000 m long. A team of conservationists make a scale model of the river that is 1 m long. What is the scale of the model?

A. 1:1

B. 1:25,000

C. 10:25

D. 2,500:1

After a consumer selects and attends to a stimulus, the perceptual process shifts its focus to ______.

Answers

After a consumer selects and attends to a stimulus, the perceptual process shifts its focus to organizing, categorizing, and interpreting the incoming information.

What is the definition of customer behaviour?

The purchase, consumption, and disposal of items, services, time, and ideas by decision-making units is referred to as consumer behaviour.

Consumer behaviour is the study of how individuals make purchasing decisions. It seeks to comprehend how customers select, utilise, and discard items and services, as well as the numerous stages people go through prior to making a purchase.

In general, there are five major aspects that influence consumer behaviour, i.e. whether a target client purchases a product or not. Psychological, social, cultural, personal, and economic considerations are among them.

learn more about  customer behaviour refer

https://brainly.com/question/28365292

#SPJ4

Annual plants (grasses) growing in a recently burned patch of forest represent the first stage in

Answers

I believe the answer would be regeneration.

The process of _____ induces the proliferation of antigen specific t cells and b cells.

Answers

The process of clonal selection induces the proliferation of antigen specific T cells and B cells.

What causes T cells to multiply?

A full-fledged spontaneous proliferation in which T lymphocytes with greater affinities to MHC-self-antigens (and commensal antigens) are activated for proliferation is brought on by the absence of any memory population.

Antigens attach to antibodies in humoral immunity, activating B cells to create plasma cells and memory B cells. Then, antigens identify them for eradication. In cell-mediated immunity, the antigen is engulfed by macrophages, which then expose it on their surface. Helper T cells attach to and activate macrophages.

Cell-mediated immune responses include the destruction of infected cells by cytotoxic T cells or the destruction of intracellular pathogens by macrophages.

Learn more about clonal selection refer

https://brainly.com/question/15902626

#SPJ4

The process of evolution by natural selection depends on the existence, in every biological population of?

Answers

The process of evolution by natural selection depends on the existence, in every biological population of genetic variability.

Genetic Variability- The capacity of the genes present to enable a cell, organism, or population to live and reproduce is known as genetic viability.

Natural Selection- An evolutionary mechanism is natural selection. Environment-adapted organisms have a higher chance of surviving and dispersing the genes that contributed to their success. Over time, this mechanism leads to the evolution and divergence of species.

Genes- The fundamental genetic component transferred from parent to child. Genes are composed of DNA sequences and are organized sequentially at specified sites on chromosome in the cell nucleus.

To know more about the genetic variability, click on the below link,

https://brainly.com/question/13952713

#SPJ4

An observation about how to solve a problem is called a

Answers

Answer:

An observation about how to solve a problem is called a theory / scientific method

Explanation:


What are the roles of oxytocin and prolactin in regulating the mammary glands?

Answers

The correct answer is Oxytocin controls milk release, while prolactin controls milk production.

Two hormones, oxytocin and prolactin, play a major role in the creation and release of milk from the breasts during the breastfeeding stage. Prolactin, whose namesake refers to milk and means "for," boosts milk production.

Contrarily, oxytocin causes the smooth muscle cells surrounding the breast glands to contract, causing the milk to be released.

During labor, oxytocin also aids in the contraction of the uterine muscle. The pituitary gland and the hypothalamus, two interrelated brain regions, are responsible for producing both of these hormones.

Thus, the hypothalamus is essentially a region of the brain made up of several nuclei, or collections of neurons.

To learn more about oxytocin refer the link:

https://brainly.com/question/1996049

#SPJ4

Blood vessels that supply nutrients and oxygen only to the heart amuscles make up the specific type of circulation called the?

Answers

Blood vessels that supply nutrients and oxygen only to the heart muscles and make up for a specific type of circulation are called pulmonary veins.

What are pulmonary veins?

Blood tubes called pulmonary veins take oxygen-rich blood from your lungs and deliver it to your heart. The pulmonary circuit of your body includes your pulmonary veins. Blood travels via this network of blood veins from your heart to your lungs. Your pulmonary arteries are also a part of this circuit.

There are two primary distinctions between your pulmonary arteries and veins:

They transport many blood kinds. Your pulmonary arteries convey blood that is low in oxygen. Blood rich in oxygen is carried through your pulmonary veins.They move in various directions. Blood travels via your pulmonary arteries from your heart to your lungs. Blood is transported to your heart from your lungs through your pulmonary veins.

Therefore, blood vessels that supply nutrients and oxygen only to the heart muscles and make up for a specific type of circulation are called pulmonary veins.

Read more about pulmonary veins, here

https://brainly.com/question/4385723

#SPJ4

a strain of streptococcus pneumoniae is no longer able to synthesize its capsule. what is the likely outcome?

Answers

A strain of Streptococcus pneumoniae is no longer able to synthesize its capsule. Its likely outcome is that it will be readily phagocytized upon entering the host.

A recent study has found that a strain of Streptococcus pneumoniae is no longer able to synthesize its capsule. This is a major concern, as this particular strain is known to be highly virulent. Without a capsule, the bacteria will be much more susceptible to phagocytosis by the host's immune cells. This could lead to a more serious infection, and potentially even death. The researchers are urging caution and urging people to get vaccinated against this strain of bacteria.

Learn more on Streptococcus pneumoniae here:

https://brainly.com/question/19317733

#SPJ4

For the wild-type hamsters that received t SCN transplants, what would have been an appropriate experimental control?

Answers

The appropriate control, in this case, would be to transplant the SCN from one wild-type hamster to another wild-type hamster.

What is SCN?

As the primary circadian pacemaker in the mammalian brain, the suprachiasmatic nucleus (SCN) of the hypothalamus produces circadian rhythms in rest and exercise, body temperature, neuroendocrine operation, autonomic, memory, and psychomotor performance, as well as a variety of other psychological and physiological processes.

The circadian timing system, a crucial brain mechanism, is controlled by the SCN (CTS).

Therefore, in the case of SCN transplants in wild-type hamsters, the appropriate control is the transplant of SCN from one wild-type hamster to another wild-type hamster.

Read more about transplants, here

https://brainly.com/question/21144644

#SPJ4

This bombardier beetle is spraying a boiling hot liquid that contains irritating chemicals, used as a defense mechanism against its enemies. The beetle stores two sets of chemicals separately in its glands. Using what you learned about chemistry in this chapter, propose a possible explanation for why the beetle is not harmed by the chemicals it stores and what causes the explosive discharge.

Answers

The two chemicals are mixed and a chemical reaction occurs that produces the boiling hot liquid that contains irritating chemicals.

What is chemical reaction?

We know that some organisms have a defense mechanism. This implies that they are able to protect themselves from attacks by the use of certain structures or chemicals in their bodies. This helps to ward off predators that may want to prey on the organism.

In this case we have the  bombardier beetle. The organisms have two separate organs that store chemicals. These chemicals do not hurt the  bombardier beetle but can be used when attacked. The chemicals are stored in different glands.

What happens is that when the bombardier beetle, the two chemicals are mixed and a chemical reaction occurs that produces the boiling hot liquid that contains irritating chemicals which is used as a defense mechanism against its enemies.

Learn more about chemical reaction:https://brainly.com/question/22817140

#SPJ1

Which statement is correct about rough ER and smooth ER?

A: Rough ER contains ribosomes, and smooth ER transports materials other than proteins.

B: Rough ER contains ribosomes, and smooth ER transports proteins.

C: Rough ER transports proteins, and smooth ER contains ribosomes.

D: Rough ER transports materials other than proteins, and smooth ER contains ribosomes.

Answers

The statement that is correct about rough ER and smooth ER is that Rough ER contains ribosomes, and smooth ER transports materials other than proteins (option A).

What is the endoplasmic reticulum?

Endoplasmic reticulum is a network of membranes within the cytoplasm of cells, where proteins and lipids are synthesized.

The endoplasmic reticulum are of two types namely;

Rough endoplasmic reticulumSmooth endoplasmic reticulum

The major difference between these two endoplasmic reticulum is that ribosomes are attached to the rough ER but not attached to the smooth ER, hence, their respective names.

This difference plays a vital role in their function because rough ER is involved in protein synthesis while the smooth ER is involved in lipid synthesis.

Therefore, the statement that is correct about rough ER and smooth ER is that Rough ER contains ribosomes, and smooth ER transports materials other than proteins.

Learn more about endoplasmic reticulum at: https://brainly.com/question/13118914

#SPJ1

Compare and contrast the ways that metabolic waste products enter the excretory systems of flatworms, earthworms, and insects.

Answers

The flatworm is made up of a model system, such as protonephridia, which aids in ISF filtering (interstitial fluid). Earthworm metabolic waste enters the interstitial fluid and consists of metanephridium involved in excretion.

What are the excretory systems of flatworms, earthworms, and insects?

The flatworm is made up of a model system, such as protonephridia, which aids in ISF filtering (interstitial fluid). Earthworm metabolic waste enters the interstitial fluid and consists of metanephridium involved in excretion.

The metabolic waste products enter the insect system via the hemolymph (extracellular fluid of insects).

Ciliated cells in flatworms draw interstitial waste products into protonephridia. Waste products from interstitial fluids enter the coelom of earthworms. Cilia then transport wastes into metanephridia via a funnel that surrounds an internal opening to the metanephridia.

The Malpighian tubules in insects pump fluids from the hemolymph, which receives waste products during an exchange with cells during circulation.

To learn more about excretory systems refer to:

https://brainly.com/question/28302813

#SPJ4

Like oil and coal, ________
is a byproduct of the natural decay
process of plant and animal material over millions of years. (2 words)
Answer

Answers

Answer:

natural gas- its another fossil fuel

Which is the best ending for : A channel .......

A. Allows ions, sugars and amino acids to diffuse themselves across the membrane
B. None of these
C. Prevents unwanted molecules from entering the cell.
D. Transport ions, sugars and amino acids across the membrane.

Answers

The answer will be d
Other Questions
In an rlc series circuit, the voltage amplitude and frequency of the source are 100 v and 500 hz, respectively, and , l = 0.20 h, and . (a) what is the impedance of the circuit? Tom keeps all of his marbles in a bag. 5 red marbles. 4 blue marbles. and three yellow are in the bag. if he randomly chooses one marble what is the probability it is blue? Question 6 of 20:Select the best answer for the question.6. Harassment is a/anO A. singleO B. repeatedO C. unsuccessfulO D. successfulattempt to harm a person. a clash of values is when one persons values do not agree with another persons values. governments are put into place to insure that the people within a country have similar values. what happens when societies do not have governments? "for so swiftly it flew the sight could not follow it in its flight " what do these lines mean? The word geometry comes from the Greek words geo, which means "earth," and metron, which means "a measuringof." Given this information, how do you think the study of geometry developed? Question 1 (Multiple Choice Worth 5 points)(01.06 LC)Which statement shows that money is a "measure of value?"This bill is worth twenty dollars.My phone is worth eight hundred dollars.The dollar I just found in my drawer is still worth a dollar.The more features it has, the more it is worth. when a court interprets laws in a way that creates or promotes social change and wrestles with moral issues, it is engaging in judicial restraint. review. activism. centers for disease control actually recommend that patients who are current tobacco users stop smoking at least one month before surgery. An insulinoma is a cancerous mass of pancreatic beta cells that secrete insulin but do not respond to feedback mechanisms. How you would expect an insulinoma to affect blood glucose levels and liver activity? _________________ is a set of commands used to control a databases, which includes security. Lesson 4 multiplication pattern70 x 500 = Activated g protein-coupled receptors can? a. bind gtp b. open an ion channel c. raise cytosolic calcium d. a and b are correct e. a, b and c are correct Question 12 (1 point)All of the following are true about Franz Boas EXCEPT heOrelied heavily on racist stereotypes, making much of his work ethicallyquestionable.used empirical methods in the field, seeking evidence that could be tested.conducted extensive field research among the Inuit of Baffin Island.redirected the field away from ethnocentric stereotypes and toward culturalrelativism. How does the consumption of macromolecules in the Inuit diet compare those in the American diet? A number added to -19 is equal to -21 The strategy used to establish the applicability of research findings obtained in one country or culture to other countries or cultures is called the________. List at least 4 places/content that most often inspire artists. Explain which inspires and draws you the most and why? Una oracin con una palabra con r y otra con rr reasons for the rise in the diversity of animal phyla during the cambrian include all of the following except: group of answer choices predators acquired novel adaptations hox genes facilitated the evolution of new forms cooling in the global climate triggered shifts in animal lineages an increase in atmospheric oxygen permitted larger bodied animals to thrive prey species acquired new defenses