Club foot is a rare disease due to congenital skeletal abnormalities, both genetic and nongenetic factors are thought to be responsible for club foot. A family in which club foot was inherited as an autosomal dominant trait with reduced penetrance was identified in 2008. It was found that a mutation in the PITXI gene that caused club foot in this family. Through DNA testing, they determined that 11 people in the family carried the PITXI mutation, but only 8 of these people had club foot.

Required:
What is the penetrance of the PIXTI mutation in this family?

Answers

Answer 1

Answer:

72.72%

Explanation:

The Penetrance of the PIXTI mutation in this family can be represented as

The Penetrance represents the percentage of people who show/have the disease

family size = 11

number of people with the disease = 8

Penetrance of PIXTI in the family can be calculated as  = 8/11 * 100

                   = 0.7272  * 100

                   = 72.72%

The remaining 27.38 % are just carriers of the PITXI gene


Related Questions

The image below shows salamander skin cells as viewed under a microscope. The activity occurring inside the rectangle best supports which scientific theory?
Temand win PDB 1000
Appeared in The
O cell theory
O germ theory
O gene theory
O endosymbiotic theory
Type here to search

Answers

Answer:

A. Cell theory.

Explanation:

The image above shows salamander skin cells as viewed under a microscope. The activity occurring inside the rectangle best supports a scientific theory known as cell theory with respect to cell division.

A cell can be defined as the fundamental or basic functional, structural and smallest unit of life for all living organisms. Some living organisms are unicellular while others are multicellular in nature.

A unicellular organism refers to a living organism that possess a single-cell while a multicellular organism has many (multiple) cells.

Cell theory states that cell is the basic unit of life, all living organisms are made up of one or more cells and they typically arise from existing cells i.e pre-existing cells give rise to new ones through the process of cell division.

From the image of the salamander's skin cell, we can see that it comprises of many cells and are these look very much alike, meaning they are from pre-existing cells.

Eukaryotic cells have membrane bound organelles and DNA contained in a nucleus.
True
False

Answers

Answer:

True

Explanation:

Eukaryotic cells DO have membrane-bound organelles and a DNA contained in the nucleus which is different from prokaryotic cells which DO NOT have membrane bound organelles and normally do not have a nucleus.

Hope this helps! Let me know!

Answer

True

Explanation

I looked it up

One suprising fact of the animal kingdom is that only approximately 5% of animals are classified into which group

Answers

Answer:

Chordates

Explanation:

Which of the following would be particularly damaging to the chaparral biome?
a.
wildfires
b.
flooding
c.
drought
d.
none of the above


ANSWER IS D- NONE OF THE ABOVE

Answers

Answer:

Wild fires

Explanation:

Because a chaparral biome is sort of a forest.

Answer:

D. None of the above

Explanation:

Chaparal Environments posses organisms that have adapted to wildfires as a result dense vegatation and low humidity during the summer , they have adapted to flooding evidently from the high amounts of precipitation during the winter months, and they have adapted to drought seeming as the majority of the inhabitance store water or adapt to use less of it.

A eukaryotic cell has 6 chromosomes, explain what you would get at the end meiosis.

Answers

Answer:

If a eukaryotic cell has 6 chromosomes, the end result after meiosis is two daughter cells with 3 chromosomes each.

Explanation:

Meiosis is the process of cell division by which sex cells or gametes are formed. It is a mechanism of reductive division, since the chromosomal charge of a eukaryotic celldiploid— is reduced by half, that is, haploid cells are obtained.

A diploid eukaryotic cell with 3 pairs (6) of chromosomes, after meiosis produces two haploid daughter cells, with 3 chromosomes each.

This process of reductional division, where the gametes are obtained, aims to ensure that when the gametes of each parent join together they form a diploid cell, the zygote.

What are the major parts of a cell

Answers

Answer:

Cell membraneNucleusCytoplasm

I hope this helps!

Answer:

Nucleus, nucleolus, ribosomes cell membrane, cytoplasm, mitochondria et cetra.

1.Which of the following is an example of nature's leftovers? Oa snake eating an entire mouse carrots left underground after the leaves have been eaten aboveground O a bird eating an entire earthworm a plant growing in a garden​

Answers

Answer:

i choose O2

Explanation:

a bird eating an entire earthworm a plant growing in a garden (confused)

an earthworm and a plant are both products of nature and that is normal between nature's survival for the fittest so a plant eating an earth worm is way of showing nature's leftovers of the earth worm and plant

which of the following statements describes a proton of an atom?
a. has a negative charge and is located in the nucleus
b. has a positive charge and is located in outer energy levels
c. has no charge and is located in the nucleus
d. has a positive charge and is located in the nucleus

Answers

Answer:

d. Has a positive charge and is located in the nucleus

Memory technique:

Think of the "p" and proton and the "p" in positive.

Think of the "neu" in neutron and "neu" in neutral.

Think about electrons and electricity. Touching something "elec"tric would hurt, or give you negative feelings.

Electrons revolve around the cell while protons and neutrons are a part of the nucleus because negative and positive things would not get along.

That's all I have! I hope this helps with your studying. Happy learning, friend! :)


POSSIBLE HYPOTHESIS:
INDEPENDENT VARIABLE
DEPENDENT VARIABLE:
EXPERIMENTAL GROUP:
CONTROL GROUP:
CONCLUSION:
Please help quick

Answers

You do know that you have to give a topic on what this project is about, also doing this quick is never gonna happen. Science projects take TIME AND EFFORT. So, with that being said, sorry for wasting your time.

When a doctor needs to give someone a medication intravenously (through a vein), they dilute that medicine in a saline solution (salty water). Why would it be a bad idea for a doctor to mix the medicine with plain water? (Hint: Osmosis is the answer, but you’ll need to explain why.)

Answers

Answer:

it is because the blood cells will have too much water in them and they will burst.

Explanation:

there will be less salt inside the cells so all the water will enter the cells. if there is also salt present outside of the cell then the water and the electrolites(salt) will equalize between the inside and the outside of the cell.

the phenomenal having lowest acidity is​

Answers

Answer: Alcohols are considered neutral with pKa values similar to water. In aqueous solutions, phenols are weakly acidic and lower the pH of a solution

Explanation:

What do your cells do when you sleep

Answers

Your body’s cells reenergize and take time to clear your brains waste and also to support the things you learned and your memory

What two basic geologic processes contributed to the formation of folded mountain ranges like in Glacier National Park?

A. Folding and breaking of ingenuous rocks and tectonic uplifting.

B. Faulting of sedimentary rock and erosion.

C. Volcanic ash buildup and faulting of rocks.

D. Folding and breaking of sedimentary rocks and erosion.

Answers

Answer:

D. Folding and breaking of sedimentary rocks and erosion.

The two basic geologic processes that contributes to the formation of folded mountain ranges are ; ( D ) Folding and breaking of sedimentary rocks and erosion

Folded mountains are formed by the collision of two or tectonic plates, the movement and collision is mostly caused by massive erosion.

Tectonic plates are formed by the breaking down of the earth's outermost layer into large rock slabs which lies on a molten layer of rock these large slabs are components/make up the  sedimentary rocks

Therefore the folding and breaking of sedimentary rocks caused by massive erosion leads to the formation of folded mountain ranges.

Hence we can conclude that The two basic geologic processes that contributes to the formation of folded mountain ranges are ; Folding and breaking of sedimentary rocks and erosion

Learn more : https://brainly.com/question/3684484

3 Ag Brt Ga PO 4 Ag₃PO4 + Gabrz
Balance or unbalanced

Answers

Answer:

I believe that this is balanced.

Answer: balenced

Explanation:

Just took a quiz on this, it was sucky but I got a few right and this was one of them <3

Which represents the cross between parent plants if one is heterzygous and has yellow-colored pods and the other is homzygous and has green-colored pods?
Yy ´ yy
YY ´ yy
Yy ´ Yy
yy ´ yy

Answers

Answer:

Its the first one

Yy is yellow (dominant) and heterozygous

yy is green (recessive)

with Yy and yy, you could only get 50% Yy(yellow) and 50% yy(green).  There is no way to make only yy or YY, and in order to make 100% Yy you would need one yy and one Yy

The cross between parent plants if one is heterozygous and has yellow-colored pods and the other is homzygous and has green-colored pods -  Yy yy

Heterozygous genotype:The presence of two different alleles at a particular gene locus.A heterozygous genotype may include one normal allele and one mutated allele or two different mutated alleles.Y for yellow and y for green then the heterozygous parent would be - Yy with yellow phenotype

Purebred genotype:

consists of gene pairs with genes that are the same allele typealso called the hozygousY for yellow and y for green then the hemzygous parent would be - yy with green phenotype

Thus, the cross would be -  Yy yy

Learn more:

https://brainly.com/question/3632061

The structure in the cell/plasma membrane that handles Facilitated Diffusion and Active Transport is built of amino acids in the Ribosomes. What is this
Macromolecule?
Nucleic Acid
Lipid
Protein
Carbohydrate

Answers

d. Protein

Proteins are synthesized by amino acids and involves the process of transcription and translation that has a process in the ribosomes as well.

Hope that helps :)!

ANSWER THIS NOW!!!!
40 points!!!
Drag each label to the correct location on the diagram.
Identify the structures of skeletal muscle.
muscle fiber
muscle
fascicle
myofilament
myofibril

Answers

Answer:

1. Muscle: soft, contractile tissue important to produce force and motion in animals.

2. Fascicle: multiple bundles of skeletal muscle fibres which is surrounded by a type of connective tissue called perimysium.

3. Muscle fibres: bundles of cylindrical organelles myofibrils formed by the fusion of myoblasts via myogenesis process.

4. Myo-fibril: basic unit of a muscle cell made of thick and thin myofilament arranged in parallel columns along the length of muscle fibres.

5. Myo-filament: strands of actin and myosin proteins which pack a muscle fiber and are force generating structures.

Explanation:

Answer:

1. Muscle: soft, contractile tissue important to produce force and motion in animals.

2. Fascicle: multiple bundles of skeletal muscle fibres which is surrounded by a type of connective tissue called perimysium.

3. Muscle fibres: bundles of cylindrical organelles myofibrils formed by the fusion of myoblasts via myogenesis process.

4. Myo-fibril: basic unit of a muscle cell made of thick and thin myofilament arranged in parallel columns along the length of muscle fibres.

5. Myo-filament: strands of actin and myosin proteins which pack a muscle fiber and are force generating structures.

Explanation:

i hope this helps :)

I need help with 02.04 science natural selection please help me this is all my points im using

Answers

01.08 ang sagot nasagot namin yan e

please help:(( Which of the following is true about gas produced in a chemical reaction?
a. When gas is formed matter has been destroyed.
b. It is impossible to capture and measure all gas produced by a chemical reaction
c. It is difficult to capture and measure all gas produced by a chemical reaction
d. Gas doesn't have any mass

Answers

Answer:

b. It is impossible to capture and measure all gas produced by a chemical reaction.

Explanation:

What does the fact that all organisms use essentially the same genetic code suggest about the origin of life?

Answers

Answer:

Well this proves that all living things may be related.

Explanation:

For example, when our ancestors had kids, their kids had their DNA, when those kids had kids, they had some DNA from their grandparents and their parents. DNA is shared by reproduction.

Answer for the question with the diagram! 40 points!

Answers

The answer is D because A shows the endoplasmic reticulum, B shows the nucleus, and C shows the mitochondria, thus D is the correct answer

What is a fault line?

Answers

a line on a rock surface or the ground that traces a geological fault

The atmosphere exerts a force on earth. Why does yhe atmosphere exert pressure on earth?

Answers

Answer:

The atmospheric molecules have energy because they have a quantifiable temperature. It vibrates and circulates, and bumps into other gas molecules. Most of them are elastic, which means that the molecules bounce off more than they stick together. The "bump" is a strength. It becomes pressure when applied over an area, such as your skin or earth's surface.

Explanation:

How much is the pressure of the atmosphere?

Pressures are determined by height (mostly by the volume of water vapor), temperature, and weather. The average air pressure, however, is 14.7 pounds per square inch, 29.92, or 1.01 to 105 paschal in regular conditions at the marine level. At 5 km altitude, atmospheric pressure is just about 50%. (about 3.1 miles).

Why is the Earth's surface under pressure so much higher? It's because the weight of all the air at that location really is measured. There's not much air around you to press down while you are high in the atmosphere. The whole atmosphere is heaped above you on the surface of the Earth. While the gas molecules are extremely light and distant, they are many!

02.01 properties of water

Answers

Answer:

i know only 3 properties

Explanation:

colourless

odourless

tasteless

Is it possible for an inverted pyramid to exist

Answers

Answer:

An inverted pyramid of numbers can be found in an ecosystem where the community contains a few producers with a very large biomass that support a larger number of smaller consumers. An inverted pyramid of numbers can also be found in an ecosystem where the community contains parasites.

What are the three types of homologies and the definitions?

Answers

Answer:

hope this helps..

Explanation:

Dependent on the level of comparison four types of homology are defined: ( 1) Iterative ( = serial = homonomy), (2) ontogenetic, (3) di- or polymor- phic, and (4) supraspecific homology. ... Scientists have recently been paying renewed attention to the homology question.

Homology is the study of likeness, the similarity between species that results from inheritance of traits from a common ancestor. The study of similarities is broken up into three main categories: structural, developmental, and molecular homology.

is the pull of gravity on an object.
O a. Mass
O b. Element
N
O c Weight
d. Matter
Moving to another question will save this response.

Answers

Answer:

Mass

Explanation:

The measure of the pull of gravity on an object is called weight. For an object to have weight it must have mass.

Is granite a igneous rock?

Answers

Answer:

Granite, coarse- or medium-grained intrusive igneous rock that is rich in quartz and feldspar; it is the most common plutonic rock of the Earth's crust, forming by the cooling of magma (silicate melt) at depth.

Explanation:

Which of these parts of the membrane help large molecules pass through it?
A. Phospholipid bilayers
B. Phosphorus groups
C. Globular proteins
D. Fatty acids

Answers

Answer:

A. Phospholipid bilayer

Explanation:

Cell membrane is a selective permeable structure in all living cells that allows the passage of some molecules and disallows some. This function of the cell membrane is attributed to the PHOSPHOLIPID BILAYER CONTENT of its structure.

The phospholipid bilayer contains both a hydrophobic end (water fearing) and hydrophilic end (water loving). The interaction of the molecules with these regions of the membrane serves as the basis for the movement of molecules across the cell membrane.

Answer:

Globular proteins! The other answer is sadly wrong.

Explanation:

I just took the quiz. Many globular proteins positioned throughout the cell membrane help the large, polar molecules across. These globular proteins in the cell membrane are the membrane proteins.

Also, I accidently put a 1 star on my own answer, but it's correct.

An igneous rock is found on the ground and has no identifiable crystals. What is the most likely origin of this rock? molten material that cooled slowly
molten material that cooled quickly
rock that was eroded by surrounding rocks
rock that was exposed to extreme pressure

Answers

Answer:

Answer is D because extreme pressure could cause something to happen to other things that might change or take place

Explanation:

Answer: the awnser is D

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